分子节律与代谢研究所
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张天鹏
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张天鹏

职称: 研究员

学位: 博士

E-mail: zhangtianpeng@gzucm.edu.cn

个人获得荣誉:beat365亚洲体育在线官网杏林青年学者

教育、工作经历

2020/10-至今    beat365亚洲体育在线官网  beat365亚洲体育在线官网   副研究员

2018/08-2020/09   暨南大学 中医学院 博士后   导师:王英教授

2013/09-2018/07   暨南大学  中药药理学 博士  导师:吴宝剑教授

2009/09-2013/07   湖北医药学院   药学  学士

研究领域及方向

研究领域:药理学
研究方向:
1生物钟调控代谢性疾病研究;(2)药物代谢动力学

代表性科研及教学课题

1. 国家自然科学基金青年项目,81903698,核受体REV-ERB调控药物处置及其作用机制研究,2020/01-2022/1221万元。(主持)

2. 中国博士后科学基金面上项目,2019M650234,时钟基因REV-ERBa调控药物代谢及其作用机制研究,2019/09-2021/0912万元。(主持)

3. 国家自然科学基金优秀青年项目,81722049,中药代谢与转运动力学,2018/01-2020/12130 万元。(参与)

4. 国家自然科学基金面上项目,81573488,外排转运蛋白影响葡萄糖醛酸化代谢及其作用机制研究,2016/01-2019/1264.8万元。(参与)

5. 国家高技术研究发展计划(863计划)2015AA02091,预测药物葡萄糖醛酸化代谢新技术新方法的探究,2015/01-2018/12122万元。(参与)

代表性文章

    1. Zhang T#, Yu F#, Xu H, Chen M, Chen X, Guo L, Zhou C, J Yu*, Wu B*. Dysregulation of REV-ERBα impairs GABAergic function and promotes epileptic seizures in preclinical models. Nat Commun. Accepted. (IF: 12.121)

       2. Guo L#, Zhang T#, Wang F, Chen X, Xu H, Zhou C, Chen M, Yu F, Wang S, Yang D, Wu B. Targeted inhibition of Rev-erb-α/β limits ferroptosis to ameliorate folic acid-induced acute kidney injury. Br J Pharmacol. 2020. doi: 10.1111/bph.15283. (IF: 7.73)

       3.   Zhang T, Chen M, Guo L, Yu F, Zhou C, Xu H, Wu B*. REV-ERBα antagonism promotes homocysteine catabolism and ammonia clearance. Hepatology. 2019,70(5):1770-1784. (IF: 14.679)

       4 . Zhang T#, Guo L#, Yu F, Chen M, Wu B*. The nuclear receptor Rev-erbα participates in circadian regulation of Ugt2b enzymes in mice. Biochem Pharmacol. 2019,161:89-97. (IF: 4.96)

       5.Yu F#, Zhang T#, Zhou C, Xu H, Guo L, Chen M, Wu B*. The Circadian Clock Gene Bmal1 Controls Intestinal Exporter MRP2 and Drug Disposition. Theranostics. 2019, 9(10): 2754-2767. (封面文章)(IF: 8.579)

       6. Chen M, Guo L, Dong D, Yu F, Zhang T*, Wu B*. The nuclear receptor Shp regulates morphine withdrawal syndrome via modulation of Ugt2b expression in mice. Biochem Pharmacol. 2019,161:163-172. (IF: 4.96)

       7.  Chen M#, Guan B#, Xu H, Yu F, Zhang T*, Wu B*. The Molecular Mechanism Regulating Diurnal Rhythm of Flavin-Containing Monooxygenase 5 in Mouse Liver. Drug Metab Dispos. 2019, 47(11):1333-1342. (IF: 3.231)

       8.   Zhang T, Yu F, Guo L, Chen M, Yuan X, Wu B*. Small Heterodimer Partner Regulates Circadian Cytochromes p450 and Drug-Induced Hepatotoxicity. Theranostics. 2018,8(19):5246-5258. (IF: 8.579)

       9.  Zhang T#, Zhao M#, Lu D, Wang S, Yu F, Guo L, Wen S, Wu B*. REV-ERBα Regulates CYP7A1 Through Repression of Liver Receptor Homolog-1. Drug Metab Dispos. 2018,46(3):248-258. (IF: 3.231)

      10.  Yu F#, Zhang T#, Guo L, Wu B*. Liver Receptor Homolog-1 Regulates Organic Anion Transporter 2 and Docetaxel Pharmacokinetics. Drug Metab Dispos. 2018,46(7):980-988. (IF: 3.231)

      11.  Dong D#, Zhang T#, Lu D#, Liu J, Wu B*. In vitro characterization of belinostat glucuronidation: demonstration of both UGT1A1 and UGT2B7 as the main contributing isozymes. Xenobiotica. 2017,47(4):277-283. (IF: 1.902)

      12.  Zhang T#, Dong D#, Lu D, Wang S, Wu B*. Cremophor EL-based nanoemulsion enhances transcellular permeation of emodin through glucuronidation reduction in UGT1A1-overexpressing MDCKII cells. Int J Pharm. 2016,501(1-2):190-8. (IF: 4.845)

      13.  Chen Z#, Zhang T#, Wu B, Zhang X*. Insights into the therapeutic potential of hypoxia-inducible factor-1α small interfering RNA in malignant melanoma delivered via folate-decorated cationic liposomes. Int J Nanomedicine. 2016,11:991-1002. (IF: 4.471)

      14. Zhang T#, Wang H#, Ye Y, Zhang X*, Wu B*. Micellar emulsions composed of mPEG-PCL/MCT as novel nanocarriers for systemic delivery of genistein: a comparative study with micelles. Int J Nanomedicine. 2015,10:6175-84. (IF: 4.471)

      15.  Zhang X#, Zhang T#, Ye Y, Chen H, Sun H, Zhou X, Ma Z, Wu B*. Phospholipid-stabilized mesoporous carbon nanospheres as versatile carriers for systemic delivery of amphiphobic SNX-2112 (a Hsp90 inhibitor) with enhanced antitumor effect. Eur J Pharm Biopharm. 2015,94:30-41. (IF: 4.604)

     16. Zhang X#, Zhang T#, Zhou X, Liu H, Sun H, Ma Z, Wu B*. Enhancement of oral bioavailability of tripterine through lipid nanospheres: preparation, characterization, and absorption evaluation. J Pharm Sci. 2014,103(6):1711-9. (IF: 2.997)

专利

    1.吴宝剑,张天鹏,邢会杰,赵梦静. BJ16的新应用. CN 201710687347.1

    2.吴宝剑,张天鹏,邢会杰,赵梦静. 黄秋葵水提取物在保护消化道功能中的应用.

           CN 201710687348.6

     3. 吴宝剑,周晓伟,张天鹏,王帅. 一种用于急性脑血管疾病后遗症的中药组方.


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