代表性研究论文
[1]Xiaocui Li#, Xiaowen Ou#, Guangkuo Luo, Xiaojun Ou, Yusha Xie, Mengdi Ying, Wei Qu, Huilin Zuo, Xiaoxiao Qi, Ying Wang, Zhongqiu Liu*, Lijun Zhu*. Mdr1a, Bcrp and Mrp2 regulate the efficacy and toxicity mesaconitine and hypaconitine by altering their tissue accumulation and in vivo residence. Toxicol Appl Pharmacol. 2020, 409：115332
[2]Xiaocui Li, Yushan Xie, Wei Qu, Xiaojun Ou, Xiaowen Ou, Chuang Wang, Xiaoxiao Qi, Ying Wang, Zhongqiu Liu *, Lijun Zhu*. Breast cancer resistance protein and multidrug resistance protein 2 mediate the disposition of leonurine-10-O-β-glucuronide. Curr Drug Metab.2020, 21(13): 1060-1067
[3]Xiaoyan Li, Yiyan Lu, Xiaojun Ou, Sijing Zeng, Ying Wang, Xiaoxiao Qi, Lijun Zhu* and Zhongqiu Liu*. Changes and sex- and age-related differences in the expression of drug metabolizing enzymes in a KRAS-mutant mouse model of lung cancer. PeerJ, 2020, 8: e10182
[4]Rongjin Sun#, Lijun Zhu#, Li Li, Wenjie Song, Xia Gong, Xiaoxiao Qi, Ying Wang, Romi Ghose, Song Gao*, Ming Hu*, Zhongqiu Liu*. Irinotecan-mediated diarrhea is mainly correlated with intestinal exposure to SN-38: Critical role of gut Ugt. Toxicol Appl Pharmacol. 2020, 398: 115032
[5]Lin Zhang#, Lijun Zhu#, Wei Qu, Fang Wu, Ming Hu, Wei Xie, Zhongqiu Liu*, Caiyan Wang*. Insight into Tartrate inhibition patterns in vitro and in vivo based on cocrystal structure with UDP-glucuronosyltransferase 2B15. Biochem Pharmacol, 2020, 172: 113753
[6]Yuhuan Li, Wenjie Song, Xiaojun Ou, Guangkuo Luo, Yushan Xie, Rongjin Sun, Ying Wang, Xiaoxiao Qi, Ming Hu, Zhongqiu Liu*, Lijun Zhu*. Breast cancer resistance protein and multidrug resistance protein 2 determine the disposition of esculetin-7-O-glucuronide and 4-Methylesculetin-7-O-glucuronide. Drug Metab & Dispos. 2019, 47 (3): 203-214
[7]Yuhuan Li, Linlin Lu, Liping Wang, Wei Qu, Wenqin Liu, Yushan Xie, Hongming Zheng, Ying Wang, Xiaoxiao Qi, Ming Hu*, Lijun Zhu*, Zhongqiu Liu*. Interplay of efflux transporters with glucuronidation and its impact on subcellular aglycone and glucuronide disposition: a case study with kaempferol. Mol Pharm. 2018, 15(12): 5602-5614.
[8]Haihui Zheng, Liping Wang, Sijing Zeng, Jiamei Chen, Haojia Wang, Jia Yu, Xia Gong, Huangyu Jiang, Xia Yang, Xiaoxiao Qi, Ying Wang, Linlin Lu, Ming Hu, Lijun Zhu*, Zhongqiu Liu*. Age-related changes in hepatic expression and activity of drug metabolizing enzymes in male wild-type and breast cancer resistance protein knockout mice. Biopharm Drug Dispos.2018, 39(7): 344-353
[9]Jiamei Chen, Qisong Zhang, Xiaoyan Li, Xia Gong, Yanjiao Ruan, Sijing Zeng, Linlin Lu, Xiaoxiao Qi, Ying Wang, Ming Hu, Lijun Zhu*, Zhongqiu Liu*. Tissue distribution and gender-specific protein expression of cytochrome P450 in five mouse genotypes with a background of FVB. Pharm Res. 2018, 35(6): 114
[10]Jiamei Chen, Haihui Zheng, Sijing Zeng, Cong Xie, Xiaoyan Li, Tongmeng Yan, Xia Gong, Linlin Lu, Xiaoxiao Qi, Ying Wang, Ming Hu, Lijun Zhu*, Zhongqiu Liu*. Profiles and gender-specific of UDP-glucuronosyltransferases and sulfotransferases expressions in the major metabolic organs of wild-type and efflux transporter knockout FVB mice. MolPharm. 2017, 9(14): 2967-2976
